Endocrine Abstracts

CYP17A1 inhibition with abiraterone is an effective treatment for castration-resistance prostate cancer (CRPC), with significant improvements in survival, radiological progression free survival, pain, skeletal related events and other secondary end-points. However, resistance invariably develops. Due to mineralocorticoid excess, abiraterone is administered with glucocorticoids. Next-generation sequencing of circulating plasma DNA from CRPC offers an opportunity to monitor tumo...

With the wide-spread use of abiraterone/enzalutamide for CRPC, there is an urgent need to understand and reverse resistance to these treatments. Studies have implicated glucocorticoid receptor (GR) as activating androgen receptor (AR) signalling and driving resistance. Here we studied progesterone receptor (PR), which is phylogenetically most closely related to the AR. We first used digital droplet PCR in prostate cancer (PCa) cell lines and observed >10 times higher level...

Enzalutamide (Enza) is a second-generation antiandrogen currently used in the clinic for treatment of metastatic prostate cancer. It significantly prolonged survival of men with metastatic castration resistant prostate cancer after chemotherapy by a median of 4.8 months in comparison to the placebo group. However, in a subset of patient’s beneficial effect of Enza cannot be observed, while others who initially respond eventually develop resistance towards the treatment. U...